Suppose you have a sixteen-page PDF document to be printed with eight pages on one side of each sheet. These samples show the outcome from different sets of settings.

Figure 1. 8-Up Booklet, Saddle Stitching, Sheet Wise style, Interleave, do not Flip backs of sheets

Figure 2. 8-Up Booklet, Perfect Binding, Work and Turn style, Fronts first then backs, do not Flip backs of sheets

Figure 3. 8-Up Booklet, Perfect Binding, Work and Tumble style, Interleave, Flip backs of sheets

Figure 4. Cut Stacks, Double-sided, Fronts first then backs reversed, Flip backs of sheet

Figure 5. Sequential, Double-sided, Fronts first then backs, do not Flip backs of sheet

Figure 6. Step and Repeat